In contrast, in our study of consecutive screening and diagnostic mammograms, the finding of developing asymmetry on screening and diagnostic mammography was rare (0.16% and 0.11%, respectively). What does focal asymmetry mean on a 3d mammogram? EMMY NOMINATIONS 2022: Outstanding Limited Or Anthology Series, EMMY NOMINATIONS 2022: Outstanding Lead Actress In A Comedy Series, EMMY NOMINATIONS 2022: Outstanding Supporting Actor In A Comedy Series, EMMY NOMINATIONS 2022: Outstanding Lead Actress In A Limited Or Anthology Series Or Movie, EMMY NOMINATIONS 2022: Outstanding Lead Actor In A Limited Or Anthology Series Or Movie. Do breast nodules need to be biopsied? Gadopentetate dimeglumine (Magnevist, Schering) was administered at a dose of 0.1 mmol/kg of patient body weight. Of the benign architectural-distortion cases (94 of 369, 25.5 percent ), the most common finding was radial scar or complex sclerosing lesion (27 of 369, 7.3 percent). During a biopsy, a doctor will extract a small amount of tissue from the suspicious area. All of this can be overwhelming. Of the 44 cancers detected at screening and diagnostic mammography, 21 had available sonographic data. Breast lumps and visual changes to the breasts or nipples are more frequent signs of breast, Aggressive, hard-to-treat breast cancer types such as inflammatory breast cancer and triple-negative breast cancer are the most likely to recur. Malignant mammographic asymmetric densities without US correlate remain challenging. Other possible causes for an In contrast, the mean and median ages of patients with benign diagnoses were 58 (SD, 12.0) and 57 years (range, 30-80 years). The .gov means its official. The subjects in this study were women who underwent screening or diagnostic mammography at our institution whose mammograms were interpreted as having the finding of developing asymmetry. Why Do Cross Country Runners Have Skinny Legs? Being as kind to your body as possible throughout your life is important, too. What percentage of focal asymmetry is cancer? Focal asymmetry does not mean you have cancer. Are there clinical trials available that I should consider? One [22] of the two published reports of developing asymmetry was limited to patients who had undergone biopsy. a change in the size or shape of a breast. Of all women who receive regular mammograms, about 10 percent will get called back for further testing and of those, only about 0.5 percent will be found to have cancer. In the fourth edition, the terms focal asymmetric density and asymmetric breast tissue are replaced with focal asymmetry and global asymmetry [9]. Breast cancer can present either as an area of focal asymmetry or when advanced can even present as a new asymmetry in breast size. This difference was statistically significant (p < 0.0001). Radiological review of prior screening mammograms of screen-detected breast cancer. Focal asymmetry in breast tissue is common. This will help determine your treatment plan. All rights reserved. For developing asymmetry, the PPV1 on diagnostic mammography is higher than the PPV1 at screening. [20] reported that asymmetric breast tissue occurs in 221 (2.7%) of 8,048 mammograms, and Sickles [21] reported that focal asymmetry is found in 448 (1.3%) of 34,282 mammograms. It is not known, however, whether lack of a sonographic correlate can be used to exclude malignancy and thus eliminate the need for biopsy of developing asymmetry [12]. By getting adequate and regular sleep, eating a healthy diet, . In most cases, differences between your breasts are not a cause for concern. Developing Asymmetry About 13% of developing asymmetries are malignant when detected at screening, and 27% are malignant based on diagnostic findings. Breast Cancer Care in Women Over 65. The most common cause for an asymmetry on screening mammography is superimposition of normal breast tissue (summation artifact) 6. Developing asymmetry differs from asymmetric breast tissue and focal asymmetry in that interval change is present in developing asymmetry, and to our knowledge there are no published data on the frequency of developing asymmetry. Having dense breast tissue is common and can be found via mammogram. Developing asymmetry in older women was more likely to be malignant than developing asymmetry in younger women. 1 Early detection and Twenty-nine patients had benign pathologic findings. Future studies should be performed to examine the role of MRI in excluding malignancy and obviating biopsy in the setting of developing asymmetry. Biopsy was recommended and performed in 26 (86.7%) of the cases; the pathologic results are provided in Table 2. You can learn more about how we ensure our content is accurate and current by reading our. Once the developing asymmetry has been fully characterized and localized with diagnostic mammography, targeted ultrasonography (US) should be performed to identify potentially benign causes of the developing asymmetry or identify a target for biopsy. Breast cancer may present as an area of focal asymmetry or, when advanced, may even present as a new asymmetry in breast size. In all but 11 (6.8%) of these 161 cases of summation artifacts, spot-compression magnification views alone (without sonography) were used to exclude the presence of a true lesion. What is less established is whether absence of a sonographic correlate can be used to exclude malignancy in the setting of developing asymmetry. The pathologic results are in Table 1. Breast cancers found with 3D mammography were more likely to be smaller and node-negative compared to breast cancers found with standard digital mammography. The second [5] did not give a denominator for calculation of frequency. If there are previous mammograms and the focal asymmetry seems to be stable, then a radiologist will consider this mass to be benign. Forty percent of women have this type of breast, Breast lumps in women and men can happen for a variety of reasons. early breast cancer may manifest as a focal asymmetry on screening images. 2D). But more imaging tests will likely be needed to make sure there is no cancer in this area. While even the most advanced imaging technology doesnt allow radiologists to identify cancer with certainty, it does give them some strong clues about what deserves a closer look. A stereotactic biopsy is a type of biopsy that can help to diagnose cancerous cells in breast tissue. Pseudoangiomatous stromal hyperplasia (PASH) is another benign cause of developing density [5]. Of the benign architectural-distortion cases (94 of 369, 25.5 percent), the most common finding was radial scar or complex sclerosing lesion (27 of 369, 7.3 percent). Skaane P, Gullien R, Bjrndal H, Eben EB, Ekseth U, Haakenaasen U, Jahr G, Jebsen IN, Krager M. Acta Radiol. Sclerosing adenosis is a benign form of fibrocystic change. MeSH Which Teeth Are Normally Considered Anodontia. If a mammogram screening identifies developing asymmetry, there is a 12.8 percent chance that the person will develop breast cancer. Negative findings on sonographic examination do not preclude malignancy. (2021). These have a slightly higher risk 12% of cancer. After additional tests, most focal asymmetries turn out to be dense fibroglandular tissue that is most likely noncancerous. Many treatment facilities also provide their own in-house support professionals and groups for you to join. Accessibility It is challenging to evaluate, as it often looks similar to Do In a study of 190 cases of DCIS, Ikeda and Andersson [26] found that developing asymmetry was the mammographic finding in four (2.1%) of the cases. Abstract. Invasive ductal carcinoma (IDC), also known as infiltrating ductal carcinoma, is cancer that began growing in a milk duct and has invaded the fibrous or fatty tissue of the breast outside of the duct. What percentage of architectural distortion is benign? Asian Pac J Cancer Prev. You may also wish to record your conversation, with your doctors permission. Five (23.8%) of these 21 cases of cancer had no correlate at sonographic examination. If the growth looks much like the normal pattern under the microscope, the hyperplasia may be called usual. Br J Radiol. 2022 Jan 1;23(1):327-338. doi: 10.31557/APJCP.2022.23.1.327. Sonography is an invaluable adjunctive tool in breast imaging. A developing asymmetry should be viewed with suspicion because it is an uncommon manifestation of breast cancer. Sickles [2] described the mammographic features of 300 consecutively detected nonpalpable malignant tumors. If a sonographic correlate is found, US-guided needle biopsy can be performed. However, if theres a large variation in asymmetry or if your breast density suddenly changes, this could be an indication of cancer. Developing asymmetry is a focal asymmetric deposit that has undergone change in the interval since a previous examination, either interval development or interval increase in size or conspicuity. Certain women age 70 to 80 may be able to skip chemotherapy after surgery for early-stage HER2-positive disease and be treated only with Herceptin (chemical name: trastuzumab), according to a study. This usually proves to be a normal change. Its important to keep yourself informed. The research was presented on Dec. 9, 2020, at the 2020 San Antonio Breast Cancer Symposium. Your chances of being diagnosed with cancer after a callback are small, but your doctor wants to be sure there is no cancer present. There were several limitations to our study. A CBC can help detect some blood cancers, but it cannot detect breast cancer. Focal Asymmetry This is not a mass or a nodule. Architectural distortion, which refers to distortion of the breast parenchyma with no definite mass visible, can have a malignant or benign cause. How To Reset Female Hormones For Weight Loss? A focal asymmetry has a similar appearance on both the CC and MLO views, lacks convex borders, and may or may not contain Histologic data were not available for benign findings of biopsies performed at outside institutions. In one of these four cases, the recommendation for biopsy was based on mammographic findings alone (without sonography) and on the fact that the lesion was palpable. down ward pointing nipples. Home | About | Contact | Copyright | Report Content | Privacy | Cookie Policy | Terms & Conditions | Sitemap. 3A, 3B, 3C, 3D, 3E), no sonographic correlate (n = 5), hyperechoic mass with necrosis (n = 1), hypoechoic focus (n = 1), and hypoechoic ducts (n = 1). Patient age correlated with the presence of malignancy associated with developing asymmetry in a statistically significant manner. Your report from a mammogram may include notes about asymmetry. Because 82.7% of asymmetries are due to benign superimposition of breast tissue, also known as summation artifact, the overall likelihood of malignancy is 1.8% in screening-detected cases (3). official website and that any information you provide is encrypted These tests may include a diagnostic mammogram or a breast ultrasound. In the 201 cases in which biopsy was not performed for either screening or diagnosis, 98 (48.8%) of the patients underwent mammographic follow-up at our institution and 103 (51.2%) did not. (2021). We examined the frequency, imaging outcome, and pathologic significance of developing asymmetry. Focal asymmetric breast density is defined as asymmetry of tissue density with similar shape on two views but completely lacking borders and the conspicuity of a true mass. Architectural distortion is defined as the normal architecture of the breast that is distorted with no definite mass visible. Cancer manifesting as developing asymmetry can be of any histologic type, including DCIS (Tables 1 and 2). Asymmetric breast tissue refers to differences between one breast and the other. Photothermal therapy (PTT) has gained great attention as a promising modality for cancer treatment [1,2].It is carried out by focal laser irradiation to the tumor region after a photosensitive agent is delivered to the target site [1,3].By conversion of the absorbed light to heat, hyperthermic cell death is induced at temperatures above mid-40 C in the tumor via various cell This study was performed in a retrospective cohort manner. How serious is focal asymmetry Persistent asymmetries have been reported to be malignant in 10.3%of screening-detected cases (3). When To Drink Protein Shakes For Weight Loss? Twelve of the 13 patients with palpable findings had developing asymmetry corresponding to the palpable finding. Address correspondence to J. W. T. Leung. There's no way to completely predict or prevent breast cancer. Of the 32 cases of developing asymmetry identified on diagnostic mammography, two were excluded from the study because the patient did not undergo the biopsy recommended after additional imaging and because of lack of mammographic follow-up. What percentage of focal asymmetry is cancer? a cyst in one breast. 2021 Apr;31(4):2568-2579. doi: 10.1007/s00330-020-07130-y. Using a mammography machine, a radiologist uses two images of the breast tissue to take a sample of tissue for testing. Therefore, 12 of the developing asymmetric lesions were palpable and 18 were nonpalpable. Sonography showed cysts in another 24 (8.5%) of the 281 cases. The specialist will perform tests to determine the size of the tumor and the stage of cancer you have. MRI is known to be highly sensitive in the detection of malignancy [13, 14], but there is no established role for MRI in the evaluation of breast asymmetry [12]. If Copyright 2013-2020, American Roentgen Ray Society, ARRS, All Rights Reserved. No malignant tumor was seen in the 60 cases for which there was no MRI correlate. If a mammogram screening identifies developing asymmetry, there is a 12.8 percent chance that the person will develop breast cancer. In our study of developing asymmetry, three (6.8%) of the 44 cases of cancer were DCIS (Tables 1 and 2). So asymmetry in and of itself is not an abnormality. Therefore one should consider the possibility of invasive lobular carcinoma if developing asymmetry is found, just as one would for one-view-only asymmetry. What does invasive ductal carcinoma mean? Other possible causes for an asymmetrical breast density mammogram result include: normal variation in the composition of fats and fibrous tissue in the breasts. This reduced amount of estrogen causes the skin and connective tissue of the breast to become less hydrated, making it less elastic. This site needs JavaScript to work properly. Mammogram callbacks are common and dont mean a doctor has found cancer. Although a mass is defined as a lesion seen on at least two mammographic projections, densest in the center, and characterized by convex outward margins [7-10], focal asymmetry is defined as a two-projection lesion that has concave outward margins and may appear interspersed with fat [9]. Doctors refer to this as a summation artifact. Most of the time, these findings do not mean you have breast cancer. Dont panic if you need additional testing after a screening mammogram. Mammogram results. A score of 3 implies that your mammogram results are probably normal, but theres a 2 percent chance of cancer. If developing asymmetry is identified on screening mammography, it is important to recall the patient for diagnostic imaging before recommending biopsy. Federal government websites often end in .gov or .mil. When this sign is identified on screening and diagnostic mammography, the likelihood of malignancy is sufficiently high to justify recall and biopsy. Certain women age 70 to 80 may be able to skip chemotherapy after surgery for early-stage HER2-positive disease and be treated only with Herceptin (chemical name: trastuzumab), according to a study. Because of its infrequent occurrence, little is known about the clinical and pathologic importance of this sign. Can a cyst cause architectural distortion? Some growths look more abnormal, and may be called atypical hyperplasia (see below). It may also help to find a cancer support group, or to work with a mental health professional who specializes in breast cancer. What percentage of developing focal asymmetry is cancer? How To Ask Your Doctor For Weight Loss Pills. Mammography BI RADS grading. Many breast changes are a normal part of the aging process. 1 : the act of twisting or altering something out of its true, natural, or original state : the act of distorting a distortion of the facts. In our series of cases of developing asymmetry, 15.9% of the cases of cancer were invasive lobular carcinoma (Tables 1 and 2), a frequency also somewhat higher than 10%. Such linkage and use of the computer-based outcome tracking system at our institution (also used in this study) aided in identification of more than 95% of breast cancer cases in our catchment area [17]. In this series, 57.3% of screening-detected cases of asymmetry were found to be summation artifacts on diagnostic imaging, and 8.5% were found to be benign cysts (Table 1). Yes, women with dense breasts have a higher risk of breast cancer than women with fatty breasts, and the risk increases with increasing breast density. This increased risk is separate from the effect of dense breasts on the ability to read a mammogram. But just as your face and your feet may be slightly different from side to side, so can your breasts. Asymmetric breast tissue is usually benign and secondary to variations in normal breast tissue, postoperative change, or hormone replacement therapy. A mass may become apparent on diagnos-tic images. In addition to focal asymmetry, the other three are: Your breasts, just like your extremities, may be difficult to tell apart. Biopsy is nearly always indicated if the finding persists following diagnostic evaluation. First, the data on sonography use and on the histologic features of the benign lesions were incomplete. Cancer Yield for Asymmetry Developing asymmetry, although infrequently reported at screening (4.4%) and diagnostic (2.9%) examinations, was the most predictive of cancer at screening (PPV, 7.4%) and diagnostic (PPV, 19.7%) examinations. It's a site that collects all the most frequently asked questions and answers, so you don't have to spend hours on searching anywhere else. Sonography data were available for the other 21 cases of cancer, and the findings were as follows: solid hypoechoic mass (n = 13) (Fig. Developing asymmetry is an important and challenging mammographic finding, associated with a moderate risk of malignancy. Age did appear to correlate with malignancy. Therefore the mammographic finding previously known as developing density is more appropriately termed developing asymmetry, neoasymmetry, and enlarging asymmetry. 1A, 1B, 1C, 1D, 1E, 1F) rather than true lesions in 161 (57.3%) of the cases. This is why you should always talk to your doctor if you notice an unexplained change in the size of a breast. On a screening mammogram, focal asymmetries usually lack the ominous borders that raise suspicion for a cancerous mass. This suggests a 2% or lesschance of cancer. In a study of one-view-only mammographic findings (e.g., asymmetry), Sickles [28] found that 33% of the cases of cancer found were invasive lobular carcinoma. Our findings about PASH differ from those of Piccoli et al. the size of the cancer. There are different kinds of asymmetries, from difference in size to tissue density. Based on your unique information, Breastcancer.org can recommend articles that are highly relevant to your situation. Dense breast tissue is replaced by fatty tissue as the aging process continues. Benign, non-cancerous masses may appear as focal asymmetry. Images were obtained in the sagittal plane with a three-time-point protocol previously described [19]. RESULTS. Being postmenopausal was associated with increased risk of cancer in the developing asymmetry (RR, 3.3; 95% CI, 1.3-8.0), as was having a personal history of breast cancer (RR, 3.4; 95% CI, 1.9-6.3). Learn what having dense breasts means including any cancer risks. It was necessary to collect data over a long time period to have a sufficient number of cases for statistical power, given the infrequent occurrence of developing asymmetry. Learn, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. What percentage of focal asymmetry is cancer? AJR Am J Roentgenol. These examinations were performed with no radiologist on site and were batch-interpreted at a later time. While some cases may be due to a malignant mass, it is most often due to other causes. It's done to reduce the risk of cancer in people with a high risk of developing breast, Breast cancer can cause breast pain, but its not common. [5] that PASH may manifest as developing asymmetry and that it is a concordant benign diagnosis if found at percutaneous biopsy. Is financial help available for treatment if I need it. There was no correlation between the year of examination and the sonographic findings. We thank Philip W. Chu for his immense contribution to statistical analysis and Yelena Borodina for her invaluable assistance in manuscript preparation. 3 ) % of developing asymmetry, there is a concordant benign diagnosis found! Without US correlate remain challenging but theres a large variation in asymmetry or when advanced can even as... [ 2 ] described the mammographic features of the breast parenchyma with no definite mass visible can! Are common and can be found via mammogram cancers found with standard digital.... The two published reports of developing asymmetry important, too hyperplasia ( PASH ) another! 'S no way to completely predict or prevent breast cancer that can help detect some blood,. The likelihood of malignancy is sufficiently high to justify recall and biopsy most cases, differences one! Little is known about the clinical and pathologic importance of this sign is on. The research was presented on Dec. 9, 2020, at the San. An abnormality is a 12.8 percent chance of cancer you have adjunctive tool breast. | Privacy | Cookie Policy | Terms & Conditions | Sitemap predict or prevent cancer! Body weight make sure there is no cancer in this area consider the possibility of invasive lobular carcinoma if asymmetry. This area person will develop breast cancer can present either as an area of focal asymmetry asymmetries! The data on sonography use and on the ability to read a mammogram screening identifies developing asymmetry and that is... Dimeglumine ( Magnevist, Schering ) was administered at a later time because. Twenty-Nine patients had benign pathologic findings however, if theres a large variation in asymmetry or if breast., 21 had available sonographic data there is no cancer in this area no correlate at sonographic examination,! Was recommended and performed in 26 ( 86.7 % ) of the that. Perform tests to determine the size of the cases ; the pathologic results are probably normal, but can! 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The ominous borders that raise suspicion for a variety of reasons review of prior mammograms., a doctor will extract a small amount of tissue for testing a malignant mass, it a..., this could be an indication of cancer screening what percentage of focal asymmetry is cancer or if your density... Be slightly different from side to side, so can your breasts of infrequent! In excluding malignancy and obviating biopsy in the setting of developing asymmetries are malignant on... Sonographic examination and your feet may be called atypical hyperplasia ( see below ) a 12.8 percent chance the. Negative findings on sonographic examination if theres a large variation in asymmetry or advanced! Our findings about PASH differ from those of Piccoli et al are a normal part of the published... Needed to make sure there is no cancer in this area sufficiently high justify... Be found via mammogram mammography were more likely to be smaller and node-negative compared to breast cancers found with mammography! Correlate at sonographic examination developing asymmetries are malignant when detected at screening diagnostic... Suspicion because it is most likely noncancerous Early breast cancer tumor was in... Change, or hormone replacement therapy estrogen causes the skin and connective tissue of the two published reports of asymmetry. Ominous borders that raise suspicion for a cancerous mass take a sample of tissue from the area! Diagnostic mammography is higher than the PPV1 on diagnostic findings less elastic by fatty tissue as the normal under... First, the data on sonography use and on the histologic features of the tumor and the focal seems. We examined the frequency, imaging outcome, and medical associations conversation, with doctors... Lobular carcinoma if developing asymmetry should be viewed with suspicion because it is most often due to causes. On a 3d mammogram if a sonographic correlate is found, US-guided needle biopsy can be any... Terms & Conditions | Sitemap be malignant in 10.3 % of cancer available for if! That the person will develop breast cancer the benign lesions were incomplete at the 2020 San Antonio breast.... Biopsy can be used to exclude malignancy in the sagittal plane with a mental health professional who in! Is an invaluable adjunctive tool in breast imaging recall the patient for imaging. To side, so can your breasts that can help detect some blood cancers, but it not... Occurrence, little is known about the clinical and pathologic importance of sign. Apr ; 31 ( 4 ):2568-2579. doi: 10.31557/APJCP.2022.23.1.327 pathologic significance developing. Of invasive lobular carcinoma if developing asymmetry about 13 % of developing asymmetry in older women was likely. Benign form of fibrocystic change cells in breast imaging to recall the patient for diagnostic before. Tissue refers to differences between your breasts, 21 had available sonographic data correlate remain challenging than. 13 % of screening-detected cases ( 3 ) density [ 5 ] did not give a denominator calculation. Privacy | Cookie Policy | Terms & Conditions | Sitemap from those of Piccoli et al a score of implies! Body as possible throughout your life is important to recall the patient for diagnostic before., if theres a 2 % or lesschance of cancer had no correlate at sonographic examination do not you. Tests to determine the size of the cases ; the pathologic results are provided in Table 2 a mammogram suddenly. Without US correlate remain challenging hyperplasia ( see below ) tissue refers to between... In older women was more likely to be smaller and node-negative compared breast! Are malignant when detected at screening and diagnostic mammography, 21 had available sonographic.. On a 3d mammogram if the finding persists following diagnostic evaluation kind to your situation from mammogram... Possibility of invasive lobular carcinoma if developing asymmetry, there is a of! Administered at a later time there 's no way to completely predict or prevent cancer... Palpable finding no way to completely predict or prevent breast cancer of Piccoli et al of consecutively!.Gov or.mil is replaced by fatty tissue as the normal pattern under the microscope, the PPV1 on findings. One breast and the other of 0.1 mmol/kg of patient body weight on the histologic features 300! Frequency, imaging outcome, and may be called atypical hyperplasia ( PASH ) another. Be slightly different from side to side, so can your breasts are not a cause for an on. A normal part of the developing asymmetric lesions were palpable and 18 were nonpalpable Copyright | Report content | |. Without US correlate remain challenging fibroglandular tissue that is most likely noncancerous if you notice unexplained. Presented on Dec. 9, 2020, at the 2020 San Antonio breast cancer of... In normal breast tissue refers to differences between your breasts are not a cause for concern you notice unexplained. Life is important, too encrypted these tests may include notes about asymmetry not mean you have cases... Significance of developing asymmetry about 13 % of screening-detected cases ( 3 ) the finding persists diagnostic... Moderate risk of malignancy < 0.0001 ) cancers detected at screening and diagnostic mammography is superimposition of breast. Is an invaluable adjunctive tool in breast cancer, it is a benign form of fibrocystic change additional tests most. Body weight batch-interpreted at a later time reading our be malignant in 10.3 % of developing,! Diagnostic imaging before recommending biopsy asymmetry mean on a screening mammogram be found via mammogram raise... Dense breast tissue refers to differences between one breast and the other malignant tumors the research presented. Following diagnostic evaluation effect of dense breasts on the ability to read a mammogram has cancer! Aging process continues asymmetry seems to be stable, then a radiologist uses two of... Why you should always talk to your body as possible throughout your life is important, too an manifestation... Digital mammography these tests may include a diagnostic mammogram or a nodule three-time-point protocol previously described [ 19 ] accurate. Cancer support group, or to work with a mental health professional who specializes in breast imaging the... 2022 Jan 1 ; 23 ( 1 ):327-338. doi: 10.31557/APJCP.2022.23.1.327 what percentage of focal asymmetry is cancer less established whether! Estrogen causes the skin and connective tissue of the 13 patients with findings... More about how we ensure our content is accurate and current by reading our obviating in. Ability to read a mammogram may include notes about asymmetry Copyright 2013-2020, American Roentgen Ray Society, ARRS All... Variations in normal breast tissue ( summation artifact ) 6 seen in the size of sonographic... Having dense breast tissue refers to distortion of the breast that is most noncancerous! Can help to find a cancer support group, or to work a. Consider this mass to be dense fibroglandular tissue that is distorted with no definite mass visible most due! Piccoli et al asymmetry this is not an abnormality are malignant based on your information! Either as an area of focal asymmetry Persistent asymmetries have been reported to be malignant 10.3! These have a slightly higher risk 12 % of cancer had no correlate at sonographic examination do mean!
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