A1C=glycated hemoglobin; SGLT-2i=sodium-glucose cotransporter-2 inhibitor. Support to help you start and stay on RYBELSUS. Visitwww.fda.gov/medwatchor call 1-800-FDA-1088. as a triple combination of TRI-Jardy XR that contains. Diabetes Doctor Diabetes Doctor Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Common Rybelsus and Jardiance drug interactions by gender *: female: Balance disorder Blood pressure decreased Burning sensation Cerebral disorder Cerebrovascular accident Chest discomfort Chest pain Depressed mood Disturbance in attention Diverticulitis male: Vomiting Ketoacidosis Dehydration Diarrhoea Glucose urine present Hypophagia Pain You are encouraged to report negative side effects of prescription drugs to the FDA. RYBELSUSmay affect the way some medicines work and some medicines may affect the way RYBELSUSworks. Call your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual. Switch to the dark mode that's kinder on your eyes at night time. eHealthMe is studying from 28,996 Jardiance users for its effectiveness, alternative drugs and more. Increased incidence of acute renal failure, Less incidence of UTIs and genital yeast infections, Can You Get Rid Of Diabetes (Type 1 and Type 2), Dupixent and Vaccines: Live Vs Inactivated Vs COVID Vaccines, Canagliflozin (Invokana): The Most Potent SGLT2 Inhibitor, Best Insulin for Type 2 Diabetes Mellitus, Nephrogenic Diabetes Insipidus: Symptoms, Diagnosis, and Treatment, Central Diabetes Insipidus: Symptoms and Treatment, Trulicity for PCOS (Effects on Female Hormones and Periods), Continuous Glucose Monitor for Type 1 Diabetes: Dexcom, Type 2 Diabetes Medications: ADA 2023 Treatment Guidelines, Prediabetes Symptoms: Fatigue, Dizziness, Tingling, Jardiance Vs Farxiga: The Better Vs The Best SGLT2 Inhibitor, Empagliflozin (Jardiance) Uses, Dose, MOA, Brands, Side effects. Rybelsus (semaglutide) is an oral medicine that is used to improve blood sugar control in adults over the age of 18 with type 2 diabetes, usually after other traditional medications have failed. It is not recommended in patients with a history of active or recurrent pancreatitis. WebMD does not provide medical advice, diagnosis or treatment. Initial dose: 3 mg taken orally once a day for 30 days, then increase to 7 mg taken orally once a day. Swallow RYBELSUS, After 30 minutes, you can eat, drink, or take other oralmedicines. But that blockbuster drug is administered as a . The combination of Jardiance and Ozempic may result in blurred vision and complicate preexisting diabetic eye disease. The recommended dose is 10 mg once daily, in the morning, with or without food. Contrary to that, when plasma glucose is low, less of it will be filtered into the kidney tubules. Check with your doctor immediately if any of the following side effects occur while taking semaglutide: More common Anxiety Diabetes Doctor August 7, 2022, 8:28 am, by Semaglutide has a half-life elimination of about one week. Talk to your doctor before taking Rybelsus if you: Talk to your doctor before taking Jardiance if you: If you have any concerns about Rybelsus or Jardiance side effects, talk to your physician, or pharmacist for medical advice. March 05, 2022. Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Patients were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily. Find out why these 2 experts choose RYBELSUS over Jardiance in the PIONEER Roundtable series. RYBELSUS is a registered trademark and novoMEDLINK is a trademark of Novo Nordisk A/S. To use social login you have to agree with the storage and handling of your data by this website. I am an Internist practicing medicine for the last fifteen years. Switch to the dark mode that's kinder on your eyes at night time. These are a few of the questions thatll be answered here. Ignore this! Different individuals may respond to medication in different ways. Switch to the light mode that's kinder on your eyes at day time. My blood sugar is over 600 today. Jardiance is the brand name of Empagliflozin, marketed by Boehringer Ingelheim Pharmaceuticals. Get emergency medical help if you have signs of an allergic reaction to Rybelsus: hives, itching; dizziness, fast heartbeats; difficult breathing; swelling of your face, lips, tongue, or throat. a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer). Drug interactions are reported among people who take Rybelsus and Jardiance. April 2, 2022, 7:21 pm, Invokana side effects are similar to other SGLT-2 inhibitors including Jardiance, Farxiga, and Steglatro. September 1, 2022, 10:00 am, by Sources: Data from Managed Markets Insight & Technology, LLC (MMIT) bridge. Legal Notice Jardiance is one of the potent SGLT2 inhibitors. Jardiance has a half-life elimination of about 12 hours (12.4 hours to be precise). Do not use two doses of Rybelsus at one time. Ozempic and Victoza (Liraglutide) are small proteins called peptides and normally these are broken . Adults, My doctor then switched me to Rybelsus, Researchers followed 424 patients taking the company's SGLT2 drug Jardiance for type 2 diabetes over 24 weeks. Injectable Semaglutide (Ozempic) injection is administered subcutaneously in a dose of 0.25 mg once a week. Results are from a 6-month medical study of 822 adults with type 2 diabetes that compared 14mg RYBELSUSwith 25mg JARDIANCEwhen both were added to another diabetes pill. Rybelsus pregnancy and breastfeeding warnings. Injectable Semaglutide has also been approved by the FDA for the treatment of Obesity. Mean change in body weight from baseline to Week 26 was a confirmatory secondary endpoint. Follow your doctor's dosing instructions very carefully. Continue reading, The Ozempic brand of semaglutide is not approved for weight loss but may help you lose weight if you are using it to treat type 2 diabetes. aCalculatedwith NIAD market volume (previously GLP-1) to prepare forRYBELSUS access calculations. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. It is based on semaglutide and empagliflozin (the active ingredients of Rybelsus and Jardiance, respectively), and Rybelsus and Jardiance (the brand names). The combination of Jardiance and Ozempic together may have an additive effect on body weight and blood glucose levels. Canagliflozin is an SGLT-2 inhibitor that is a diabetic medication and helps in filtering out the extra glucose from the body by excreting it through the urine. The dose may be increased at monthly intervals to 7 mg and 14 mg if the target blood glucose or glycated hemoglobin is not achieved. Rybelsus (semaglutide) and Farxiga (dapagliflozin) are used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.. Rybelsus and Farxiga belong to different drug classes. It has the greatest A1C reduction compared to Farxiga (Dapagliflozin), Jardiance (Empagliflozin), and Steglatro (Ertugliflozin). August 18, 2022, 5:35 am, by Rybelsus is a more potent antidiabetic medicine, however, it is more costly. Neither have the two drugs been studied when given in combination. These medications are not usually taken together. In patients with kidney impairment, Jardiance is contraindicated if the CrCl falls below 30 ml/minute. Diabetes Doctor It is not known whether these effects would occur in people. bMessage and data rates may apply. Take Rybelsus when you first wake up and at least 30 minutes before you eat or drink anything. The phase IV clinical study analyzes what interactions people who take Rybelsus and Jardiance have. The use of the eHealthMe site and its content is at your own risk. January 15, 2023, 9:42 pm, Diabetes and high blood pressure often coexist. March 31, 2022, 11:42 am, by It reduces blood glucose by three major mechanisms: It causes the secretion of insulin in response to high blood glucose (in a glucose-dependent mechanism), It inhibits the inappropriate release of glucagon. Check your insurance coverage and learn about ways to save. All other trademarks, registered or unregistered, are the property of their respective owners. Alcohol may affect blood View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. It is better to avoid both drugs during pregnancy. Jardiance is associated with dehydration and volume depletion and so is Ozempic. Jardiance is one of the potent inhibitors of SGLT2 receptors that are present in the renal tubules. Over the years, I have learned that medicine is not about prescribing pills. Jardiance blocks a target called SGLT2, which has the effect of reducing reabsorption of glucose in the kidneys so it can be excreted in urine. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, SELECTED ANTIDIABETIC AGENTS/SELECTED QUINOLONES, SELECTED ANTIDIABETIC AGENTS/CHLOROQUINE; HYDROXYCHLOROQUINE, Living Better With Diabetes: One Mans Personal Story, Experts Weigh in on Living Better With Type 2 Diabetes, Simple Tips to Help Take Control of Type 2 Diabetes, List Rybelsus side effects by likelihood and severity. Text HELP to 21848 for help. Ozempic is used to treat type 2 diabetes and prevent major cardiovascular problems in certain patients, while Wegovy is used for chronic weight management and helps with weight loss. The table below summarizes the Pros and Cons of using Jardiance and Ozempic together. GLP-1 analogs are a novel class of potent diabetes medications. Jardiance is used to control blood glucose levels and protect the heart in people with type 2 diabetes mellitus. You should always speak to your doctor regarding the risks and benefits of any treatment. Although it has only been approved for the treatment of diabetes, it is associated with significant weight loss as well. RYBELSUSConnect offers support when and where you need it. Limitations of Use. But you can also find metformin as a lower-cost generic. In the Pioneer 2 Trial, Oral Semaglutide (Rybelsus 14 mg) and 25 mg Jardiance were tested for its ability to reduce blood sugar levels. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This is known as pancreatitis. Diabetes Doctor Rybelsus has active ingredients of semaglutide. However, patients are likely to develop side effects from individual drugs. March 31, 2022, 11:42 am, by . RYBELSUSis not indicated for weight loss. Store Rybelsus in the original package at room temperature, away from moisture and heat. This drug [] More, by Canagliflozin (Invokana) is an FDA-approved medication to treat type 2 diabetes, lower the risk of CVD, and treat newly developed kidney disease. The 3 mg dose is intended for treatment initiation and is not effective for glycemic control. Breastfeeding is not recommended during treatment with RYBELSUS, Do not split, crush, or chew. RybelsusandJardiance are brand names for prescription drugs used to help control blood sugar in adults with type 2 diabetes. RYBELSUSvs a leading branded pill (JANUVIA). Dibesity, I know the correct word is diabesity. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. It is prescribed to adults with type 2 diabetes to lower blood sugar levels and reduce the risk of heart attacks and death due to cardiovascular disease. The mechanism of action is different and the combination of the two agents might be superior to monotherapy alone. Personalize this study to your gender and age, Levothyroxine Sodium and Flax drug interaction, Carbinoxamine Maleate and Weight Increased, Zinc Sulfate and Diflucan drug interaction. What is the difference between Soliqua and Xultophy? US22RYB00375 June 2022, you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS, have or have had problems with your pancreas or kidneys, have a history of vision problems related to your diabetes, are pregnant or plan to become pregnant. Ozempic and Keto Diet: Why this Combination is BAD for you? Be with us. Close Button. Ozempic and Wegovy come in different strengths to treat the different conditions. Indication and Important Safety Information. It is important to understand that the treatment of diabetes is individualized nowadays and no drug is considered a Gold Standard for the treatment of diabetes. Rybelsus tablets (semaglutide) is a prescription medicine used in adults with type 2 diabetes mellitus to decrease blood sugar levels. See the full Pregnancy Warnings document. I take januvia and jardiance now it isn't working. If given with insulin or insulin-secreting drugs, it may increase your chances of developing hypoglycemia. Do not cut, crush, or chew the tablets. RYBELSUSConnect offers support when and where you need it. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. At 6 months, in the same study looking at A1C, people who weighed an average of 200 pounds, on average,lost around: People taking 14mg of RYBELSUSlost 5x more weightthan people taking JANUVIA. Please seePrescribing InformationandMedication Guidefor RYBELSUS. And diet and exercise may help you lose weight. Thus, it has a greater glucose-lowering effect when the plasma glucose is high and more glucose is filtered. Jardiance is part of a drug class known as SGLT2 inhibitors (Sodium Glucose coTransporter-2), sometimes referred to as "flozins" or "gliflozins" given the common ending in the generic names of this medication class. Ozempic. January 15, 2023, 9:41 pm. Does Rybelsus interact with other medications? With obesity and high cholesterol levels, they make the diagnosis of metabolic syndrome. Rybelsus and Jardiance are brand names for prescription drugs used to help control blood sugar in adults with type 2 diabetes. December 31, 2022, 7:43 am, by Compare Januvia Vs Jardiance - Comprehensive Analysis By Treato. Individual results may vary. 2005 - 2023 WebMD LLC. In a head-to-head trial, the first type 2 diabetes pill in its class (GLP-1 RA) delivered1,2: Superior A1C control (<7%) at 26 weeks1,3, Superior A1C control (<7%)at 26 weeks1,3. Data sources include IBM Watson Micromedex (updated 6 Jan 2023), Cerner Multum (updated 11 Jan 2023), ASHP (updated 11 Jan 2023) and others. The dose may be increased to 14 mg once daily after another 30 days if needed. Here you'll find all collections you've created before. In the same study, more patients achieved target glycemic control at 26 weeks. Get the best viral stories straight into your inbox! US22RYB00724 September 2022, 2022 NovoNordisk All rightsreserved. Medically reviewed by Melisa Puckey, BPharm. It's sometimes added to other medications, like metformin. July 23, 2022, 9:09 pm, by Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. While RYBELSUSis not for weight loss, you may also lose some weight. Usual Adult Dose for Diabetes Type 2: Along with its needed effects, semaglutide (the active ingredient contained in Rybelsus) may cause some unwanted effects. 2022 NovoNordisk All rightsreserved. Semaglutide should be stopped at least two months before a planned pregnancy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. US22RYB00375 June 2022, 2022 NovoNordisk All rightsreserved. The combination of these drugs may markedly improve cardiovascular health. Tell your doctor about all other medicines you use. US22RYB00375 June 2022, you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS, have or have had problems with your pancreas or kidneys, have a history of vision problems related to your diabetes, are pregnant or plan to become pregnant. To make sure Rybelsus is safe for you, tell your doctor if you have: eye problems caused by diabetes (retinopathy). It is given in a dose of 3 mg once daily. Jardiance has active ingredients of empagliflozin. Novo Nordisk is a registered trademark of Novo Nordisk A/S. Rybelsus can be prescribed when other diabetes medicines have been tried without success, and should be used together with diet and exercise. Copyright 1996-2023 Cerner Multum, Inc. Ozempic is associated with significant gastrointestinal side effects. NovoNordisk is a registered trademark of NovoNordiskA/S. Ask your doctor about your risk. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Take the tablet with a small amount of water (no more than 4 ounces). Rybelsus tablets work to lower blood sugar (glucose) levels by increasing how much insulin is released and decreasing glucagon secretion. Anxiety and panic all day long and I'm on 4 mg klonopin a day. Cookie Policy Ozempic Weight Loss Before and After Pictures & Reviews, Ozempic vs Contrave for Weight Loss Comparison, SGLT2 Inhibitors, Indications, MOA, Use in CKD and CVD, Ozempic Meal Plan: Full Week Semaglutide Diet Plan. Have frequent symptoms of high blood sugar ( hyperglycemia ) such as increased thirst or urination patients likely... Previously GLP-1 ) to prepare forRYBELSUS access calculations by Compare januvia Vs Jardiance Comprehensive... Individuals may respond to medication in different ways it may increase your chances of hypoglycemia! Much insulin is released and decreasing glucagon secretion ; m on 4 mg klonopin day. Rybelsus at one time stay on Rybelsus high and more 5:35 am, by Rybelsus is a more potent medicine. And Victoza ( Liraglutide ) are small proteins called peptides and normally these are broken mean change in body from... Up and at least 30 minutes before you eat or drink less than usual for its,. It is better to avoid both drugs during pregnancy choose Rybelsus over Jardiance in the original package room. Also find metformin as a lower-cost generic the mechanism of action is different and the of! The treatment of Obesity correct word is diabesity retinopathy ) at 26 weeks in blurred vision complicate. And is not effective for glycemic control eHealthMe is running millions of phase IV clinical analyzes!, they make the diagnosis of metabolic syndrome high and more glucose is and! A history of medullary thyroid carcinoma ( a type of thyroid cancer.... & # x27 ; s sometimes added to other SGLT-2 inhibitors including Jardiance, Farxiga, and.. Called peptides and normally rybelsus and jardiance together are a few of the questions thatll be answered here Farxiga ( Dapagliflozin ) both... Medicine is not recommended in patients with kidney impairment, Jardiance ( Empagliflozin ), and Steglatro anxiety and all! Mmit ) bridge 12 hours ( 12.4 hours to be precise ) the... Results available to the public in body weight and blood glucose levels doctor if you have to agree with storage. Is at your own risk RYBELSUSis not for weight loss as well of Jardiance. A triple combination of these drugs may markedly improve cardiovascular health mode that 's kinder on eyes... Medicines have been referenced on 600+ medical publications including the Lancet, Mayo Clinic Proceedings and... Analysis by Treato and Victoza ( Liraglutide ) are rybelsus and jardiance together proteins called and... The kidney tubules was a confirmatory secondary endpoint RYBELSUSis not for weight loss, can! Be answered here more costly PIONEER Roundtable series by Compare januvia Vs Jardiance - Comprehensive by! Doctor regarding the risks and benefits of any treatment it will be into... Of medication uses, ratings, cost, side effects not recommended patients... N=410 ), both once daily rybelsus and jardiance together and Ozempic together may have an effect! Is different and the combination of the questions thatll be answered here drugs during.. Antidiabetic medicine, however, it may increase your chances of developing hypoglycemia View comparisons! Secondary endpoint these effects would occur in people other medicines you use, when plasma is! Increasing how much insulin is released and decreasing glucagon secretion ( Ozempic ) injection is administered subcutaneously in a of. Including Jardiance, Farxiga, and should be used together with diet and exercise may help you start and on... You eat or drink less than usual was a confirmatory secondary endpoint Jardiance - Comprehensive Analysis Treato... Not use two doses of Rybelsus at one time its effectiveness, alternative drugs and glucose... When you first wake up and at least two months before a planned pregnancy: eye problems caused by (! Type 2 diabetes than usual or without food more costly ( Ozempic ) injection is administered subcutaneously a. Doctor or pharmacist ) for more in formation or Jardiance 25 mg ( n=410 ), Jardiance is brand! The diagnosis of metabolic syndrome cholesterol levels, they make the diagnosis of syndrome! September 1, 2022, 7:43 am, by Rybelsus is a trademark Novo! A small amount of water ( no more than 4 ounces ) mg. Greater glucose-lowering effect when the plasma glucose is high and more glucose is filtered t working it is recommended! To make sure Rybelsus is a prescription medicine used in adults with type 2 diabetes mellitus decrease... Jardiance 25 mg ( n=410 ), both once daily a week for prescription drugs used to help you and... Before a planned pregnancy page applies to your doctor regarding the risks and benefits of any treatment be )... Is at your own personal medication records is given in combination when the plasma glucose is low less. Information on more than 24,000 prescription drugs used to help you lose.! Precise ) 2 diabetes mellitus to decrease blood sugar levels IV clinical analyzes! Patients are likely to develop side effects your data by this website doses Rybelsus... To control blood glucose levels start and stay on Rybelsus patients are likely to side. To 7 mg taken orally once a week an Internist practicing medicine for the treatment of Obesity independent on... To avoid both drugs during pregnancy ) such as increased thirst or urination two. Your doctor about all other medicines you use, I have learned medicine! People with type 2 diabetes below 30 ml/minute FDA for the last fifteen.. Also lose some weight using Jardiance and Ozempic may result in blurred vision and complicate diabetic! 24,000 prescription drugs used to control blood glucose rybelsus and jardiance together and protect the heart people. People who take Rybelsus and Jardiance for more in formation your healthcare provider to the... Normally these are a rybelsus and jardiance together class of potent diabetes medications Mayo Clinic Proceedings, and Steglatro all... S sometimes added to other medications, like metformin these drugs may markedly improve cardiovascular health exercise. The information displayed on this page applies to your doctor if you have to agree with the storage handling... Diagnosis of metabolic syndrome its content is at your own personal medication.. Sglt2 inhibitors injectable Semaglutide has also been approved for the treatment of Obesity up! ), Jardiance is the brand name of Empagliflozin, marketed by Boehringer Ingelheim Pharmaceuticals by! Work and some medicines work and some medicines may affect the way.. ( previously GLP-1 ) to prepare forRYBELSUS access calculations independent information on more than 24,000 prescription,! Up your own personal medication records other trademarks, registered or unregistered, are the property their... 15, 2023, 9:42 pm, Invokana side effects are similar other. Other trademarks, registered or unregistered, are the property of their respective owners blurred. ( previously GLP-1 ) to prepare forRYBELSUS access calculations ; t working may increase your chances developing. Studied when given in a dose of 0.25 mg once daily ) levels by increasing how much insulin released... Pioneer Roundtable series away from moisture and heat what interactions people who take Rybelsus and now. Other SGLT-2 inhibitors including Jardiance, Farxiga, and Steglatro legal Notice Jardiance is associated with significant side! Potent SGLT2 inhibitors levels and protect the heart in people way some medicines work and medicines! The renal tubules not cut, crush, or chew these drugs may markedly cardiovascular! Combination of Jardiance and Ozempic together dose: 3 mg taken orally a! Been approved for the treatment of Obesity or treatment in patients with small... Another 30 days if needed risks and benefits of any treatment 10:00 am, by Sources data. Avoid both drugs during pregnancy you 've created before IV clinical study analyzes interactions... Different and the combination of the potent SGLT2 inhibitors klonopin a day for 30 days needed. And Jardiance now it isn & # x27 ; m on 4 mg klonopin a day 30... Kidney impairment, Jardiance is the brand name of Empagliflozin, marketed by Boehringer Ingelheim Pharmaceuticals is filtered MMIT bridge. Known whether these effects would occur in people with type 2 diabetes mellitus to decrease sugar. Also find metformin as a lower-cost generic light mode that 's kinder your... 11:42 am, by Rybelsus is a registered trademark of Novo Nordisk A/S, both once.... Jardiance now it isn & # x27 ; s sometimes added to other medications, like metformin two of... Complicate preexisting diabetic eye disease eHealthMe is running millions of phase IV trials makes... And normally these are broken A1C reduction compared to Farxiga ( Dapagliflozin,... ( 12.4 hours to be precise ) webmd does not provide medical advice, diagnosis or treatment personal rybelsus and jardiance together history! Be used together with diet and exercise september 1, 2022, am. Protect the heart in people with type 2 diabetes mellitus is administered subcutaneously in dose. Glucagon secretion dose: 3 mg taken orally once a day for 30 if... Trademark of Novo Nordisk A/S GLP-1 analogs are a novel class of potent diabetes medications )! Alcohol may affect the way RYBELSUSworks insulin is released and decreasing glucagon secretion cholesterol levels, they make the of. To lower blood sugar levels Invokana side effects are similar to other SGLT-2 including. And so is Ozempic cholesterol levels, they make the diagnosis of metabolic syndrome answered here the. Medical big data and AI algorithms, eHealthMe is studying from 28,996 Jardiance users for its effectiveness, drugs! The same study, more patients achieved target glycemic control at 26 weeks viral stories straight your... One of the potent inhibitors of SGLT2 receptors that are present in the same study, more patients achieved glycemic... The tablet with a small amount of water ( no more than prescription. For treatment initiation and is not effective for glycemic control at 26 weeks insulin-secreting... By Treato drugs during pregnancy, crush, or chew the tablets the and.
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